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Cancer Gene Therapy
"Virally Directed Cytosine Deaminase/5-fluorocytosine Gene Therapy Enhances Radiation Response in Human Cancer Xenografts."
November 24th, 1997
According to the authors' abstract of an article published in Cancer Research, "Gene therapy combined with radiation therapy to enhance selectively radiation cytotoxicity in malignant cells represents a new approach for cancer treatment. We investigated the efficacy of adenoviral (Ad5)-directed cytosine deaminase/5-fluorocytosine (CD/5-FC) enzyme/prodrug gene therapy to enhance selectively the tumoricidal action of ionizing radiation in human cancer xenografts derived from a human squamous carcinoma cell line (SQ-20B). Tumor xenografts grown in hindlimbs of nude mice were transfected with an adenoviral vector (Ad.CMV.CD) containing the cytosine deaminase (CD) gene under the control of a...
Source: Cancer Weekly (1997-11-24)
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