Cancer Weekly
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Liposomes
"Anti-HER2 Immunoliposomes for Targeted Therapy of Human Tumors."
November 24th, 1997
According to the authors' abstract of an article published in Cancer Letters, "Anti-HER2 immunoliposomes (ILs) have been constructed by conjugation of Fab' fragments of recombinant humanized monoclonal antibody rhuMAbHER2 to small sterically stabilized unilamellar liposomes, to create a targeted drug delivery vehicle for the treatment of HER2 (c-erbB-2, neu)-overexpressing cancers. Parameters affecting in vitro binding and internalization of ILs include liposome composition, Fab' linkage site, and Fab' density. Anti-HER2 ILs have been constructed to optimize intracellular drug delivery. Doxorubicin (dox)-loaded ILs are highly stable and exhibit prolonged circulation in rats. In nude...
Source: Cancer Weekly (1997-11-24)
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