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Ovarian Cancer
"Increased Matrix Metalloproteinase-9 Activity in Human Ovarian Cancer Cells Cultured with Conditioned Medium from Human Peritoneal Tissue."
November 24th, 1997
According to the authors' abstract of an article published in Clinical & Experimental Metastasis, "Ovarian cancer cells disseminate by attachment to the peritoneal mesothelial cell surface of the abdominal cavity. We therefore investigated the influence of conditioned medium (CM) from human peritoneal tissues and mesothelial cells on the secretion of matrix metalloproteinases (MMPs) by ovarian cancer cells. The molecular weights of MMPs stimulating factors derived from human peritoneal tissues and mesothelial cells were estimated using microconcentrators with various cut-off membranes. Human peritoneal tissues were obtained from 12 surgical patients, and mesothelial cells were isolated...
Source: Cancer Weekly (1997-11-24)
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