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Prostate Cancer
"Inhibition of Osteoblastic Cell Differentiation by Conditioned Medium Derived from the Human Prostatic Cancer Cell Line PC-3 in vitro."
November 24th, 1997
According to the authors' abstract of an article published in Journal of Cellular Biochemistry, "Human prostatic carcinoma frequently metastasizes to bone tissue and activates bone metabolism, especially bone formation, at the site of metastasis. It has been reported that an extract of prostatic carcinoma and conditioned medium (CM) of a human prostatic carcinoma cell line, PC-3, established from a bone metastastic lesion, stimulate osteoblastic cell proliferation. However, there is little information about the effect of PC-3 CM on the differentiation of osteoblastic cells. In this study, we investigated the effect of PC-3 CM on the differentiation of two types of osteoblastic cells,...
Source: Cancer Weekly (1997-11-24)
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