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Cancer Immunotherapy
"DNA Vaccines Targeting Dendritic Cells for the Immunotherapy of Cancer."
November 24th, 1997
According to an abstract submitted by the author to the 3rd European Conference on Gene Therapy of Cancer, held September 11-13, 1997, in Berlin, Germany, "A number of genes encoding tumor-associated antigens recognized by MHC-restricted CD8+ T lymphocytes have recently been identified, particularly for malignant melanoma. Dendritic cells are potent antigen presenting cells capable of priming tumor-specific T cell responses in vitro and in vivo. We have developed an in vitro vaccine model for the immunotherapy of melanoma using cultured PBMC-derived DC as stimulators and naive T cells from healthy donors as responders. DC pulsed with synthetic melanoma peptides or transfected...
Source: Cancer Weekly (1997-11-24)
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