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Cancer Immunotherapy
"Different Approaches for IL-4 Gene Transfer Can Be Effective in the Treatment of Experimental Gliomas."
November 24th, 1997
According to an abstract submitted by the author to the 3rd European Conference on Gene Therapy of Cancer, held September 11-13, 1997, in Berlin, Germany, "The anti-tumor activity of interleukin 4 (IL-4) seems to be partially T cell independent. This makes this cytokine an attractive candidate for gene therapy of glioblastoma (GBM), a tumor that escapes immune surveillance also by depressing T lymphocytes activity. To evaluate the therapeutic potential of IL-4, we compared different ways of IL-4 gene transfer. We initially co-inoculated two different retroviral producer cell lines (VPC), transducing the murine IL-4 cDNA, with C6 rat glioma cells (1:1 ratio) in the brain of...
Source: Cancer Weekly (1997-11-24)
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