Cancer Weekly
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Vector Development
Alterations to Adenovirus Increase Gene Transfer Ability
November 24th, 1997
Modifications to the adenovirus (Ad) fiber coat protein produces Ad vectors with increased in vitro and in vivo gene transfer abilities. Thomas J. Wickham and colleagues from the University of Pittsburgh, Pennsylvania, and GenVec, Inc., Maryland, collaborated on the development of Ad vectors with increased delivery efficiency to targeted tissues ("Increased In Vitro and In Vivo Gene Transfer by Adenovirus Vectors Containing Chimeric Fiber Proteins," Journal of Virology, November 1997;71(11):8221-29). "Alteration of the natural tropism of adenovirus will permit gene transfer into specific cell types and thereby greatly broaden the scope of target...
Source: Cancer Weekly (1997-11-24)
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