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Vector Mechanics
AAV Transduction Efficiencies Mediated by Donor Cell Receptors
November 24th, 1997
Donor cell receptor variations correlate with transduction efficiencies of adeno-associated virus type 2 (AAV) in hematopoietic cells. In previous research, Selvarangan Ponnazhagan and colleagues suggested that AAV infection of human cells might be receptor-mediated (J. Gen. Viro., 1996;77:1111-12). To gain a better understanding of recombinant-virus-mediated transduction in primary human cells, Ponnazhagan et al. continued their work and investigated the ability of AAV to infect primary human hematopoietic progenitor cells capable of multilineage differentiation ("Adeno-Associated Virus Type 2-Mediated Transduction in Primary Human Bone Marrow-Derived CD34+...
Source: Cancer Weekly (1997-11-24)
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