"Association between High Levels of NGF and Seropositivity to KSHV/HHV8 in HIV Patients with Kaposi's Sarcoma."

According to an abstract submitted by the authors to the 37th ICAAC, held September 28 - October 1, 1997, in Toronto, Ontario, Canada, "Nerve growth factor (NGF) is synthesized and released under basal conditions by normal human B lymphocytes which also constitutively express both p75NGFR and p140trk-A receptor chains. In addition endogenous NGF functions in an autocrine fashion to maintain viability of memory B cells. Increased levels of NGF in sera from patients affected by some autoimmune diseases have been reported. It is conceivable that immune dysfunction involving B cells, as seen in the course of HIV infection, can result in abnormal NGF production and function. We measured in...

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