Hematology
"Stem Cell Factor Enhances Interleukin-2-Mediated Expansion of Murine Natural Killer Cells in vivo."
Published in Cancer Weekly, December 22nd, 1997
According to the authors' abstract of an article published in Blood, "The administration of low dose interleukin-2 (IL-2) results in a selective expansion of natural killer (NK) cells in vivo, and promotes the differentiation of NK cells from hematopoietic precursor cells in vitro. We have previously shown that stem cell factor (SCF), the ligand to the c-kit tyrosine kinase receptor, enhances IL-2-induced NK cell proliferation and differentiation in vitro. Here, we investigated the effects of SCF plus IL-2 delivered to mice in vivo. Eight-week-old C57BL/6 mice were treated with a continuous subcutaneous infusion of IL-2 (1x104 IU/d) plus a daily intraperitoneal dose of SCF...
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Source: Cancer Weekly (1997-12-22)
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