Cancer Gene Therapy

Retrovirus-Mediated Gene Transfer of IFN(alpha) into Leukemic Cells

Published in Cancer Weekly, February 2nd, 1998

The retroviral-mediated gene transfer of interferon-(alpha) (IFN(alpha)) into leukemic cells may afford patients a new therapeutic option.

The systemic administration of IFN(alpha) has been shown to induce remission and prolong survival in some patients with chronic myelogenous leukemia (CML). J.D. Lutton, representing colleagues from The Rockefeller University, New York, presented data at the 39th Annual Meeting of the American Society of Hematology, held December 5-9, 1997, in San Diego, California, which suggested that the administration of CML cells modified to secrete IFN(alpha) might also be therapeutically advantageous (abstract "Retroviral Gene Transfer of...

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Source: Cancer Weekly (1998-02-02)

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