Antisense Technology
"Antiproliferative Effects of c-myc Antisense Oligonucleotide in Prostate Cancer Cells: A Novel Therapy in Prostate Cancer."
Published in Cancer Weekly, February 16th, 1998
According to the authors' abstract of an article published in Urology, "Objectives: To explore the possibility of using antisense oligonucleotide therapy for prostate cancer, we investigated the effect of c-myc-antisense-oligonucleotide (c-myc-As-ODN) in human prostate cancer cell lines such as LNCaP, PC3, and DU145. Methods: LNCaP, PC3, and DU145 cells were incubated in the presence of c-myc-As-ODN. Dose (0 to 10 (mu)M) and time dependent (1 to 6 days) effects on proliferation and viability were examined by [H-3]thymidine incorporation and MTT assay, respectively. Flow cytometry analysis was carried out to analyze cell cycle status by determining the DNA content in...
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Source: Cancer Weekly (1998-02-16)
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