Pathogenesis

Hormonal Control of Rare Leukemia Sheds Light on Molecular Basis of Cancer

Published in Cancer Weekly, March 2nd, 1998

When researchers at the University of Pennsylvania Medical Center clarified the biochemical mechanism behind acute promyelocytic leukemia (APL), they simultaneously elucidated a process implicated in many other cancers.

APL is a bone marrow cancer that strikes about 3,000 people in the United States every year.

"This study gets at the exact biochemical and genetic cause of the uncontrolled cell growth in this leukemia," said Mitchell A. Lazar, MD, PhD, chief of the division of endocrinology, diabetes, and metabolism. "Understanding the molecular basis of this disease will teach us important lessons about cancer in general."

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Source: Cancer Weekly (1998-03-02)

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