Published in Cancer Weekly, March 9th, 1998
Numerous suicide gene therapy models have explored the bystander effect mediated by herpes simplex virus thymidine kinase (HSVtk) gene/ganciclovir (GCV) treatment. Typically these involve inserting a mixture of parental tumor cells and HSVtk gene-transduced cells into the animal followed by GCV administration.
In a clinical situation, however, this admixture before hand is not possible. Japanese researchers Hiroki Namba and colleagues developed a therapeutic approach whereby the bystander effect associated with the...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.