"Molecular Mechanisms Underlying T Cell Migration Responsible for IL-12-Induced Tumor Regression."

According to an abstract submitted by the authors to the International Symposium on Recent Advances of Human Tumor Immunology and Immunotherapy, held February 8-10, 1998, in Sapporo, Japan, "IL-12 has pleiotropic effects on T cells and natural killer (NK) cells including the stimulation of lymphokine expression, especially of IFN-gamma. It is also evident that this cytokine has potent anti-tumor activity in a number of murine tumor models. Because IL-12 itself does not act directly on tumor cells to affect the growth, the anti-tumor effect of IL-12 would involve the processes mediated by the host immune system. Among various IL-12 bioactivities, the critical requirement of IFN-gamma for...

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