Published in Cancer Weekly, March 23rd, 1998
T cells and macrophages are easily infected by HIV. Once inside the cells, the virus is no longer accessible to neutralizing antibodies. This makes HIV an ideal candidate for intracellular gene therapy.
Paul Zhou and colleagues from the U.S. National Institutes of Health, Maryland, constructed plasmids containing single chain Fv (scFv) non-neutralizing human anti-HIV-1 gp41 Ab cDNA and tested their anti-HIV activity in vitro ("Cells Transfected with a Non-Neutralizing Antibody Gene are Resistant to HIV Infection: Targeting the Endoplasmic Reticulum and...
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