Drug Resistance
"Frequent Coexpression of MRP/GS-X Pump and gamma-Glutamylcysteine Synthetase mRNA in Drug-Resistant Cells, Untreated Tumor Cells, and Normal Mouse Tissues."
Published in Cancer Weekly, March 30th, 1998
According to the authors' abstract of an article published in Biochemical Pharmacology, "Expression of the multidrug-resistance protein gene MRP, which confers non-P-glycoprotein-mediated multidrug resistance, has been found in many drug-resistant variants and tumor samples. Recent studies have demonstrated that MRP functions as an ATP-dependent transporter functionally related to the previously described glutathione-conjugate (GS-X) pump. We have shown recently that the MRP and gamma-glutamylcysteine synthetase (gamma-GCS) heavy subunit mRNA levels are coordinately overexpressed in cisplatin (CP)-resistant human leukemia cells (Ishikawa et al., Biol Chem 1996;271:14981-14988) and...
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Source: Cancer Weekly (1998-03-30)
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