Kaposi's Sarcoma
"Thiol Redox Modulation of Tumor Necrosis Factor-alpha Responsiveness in Cultured AIDS-Related Kaposi's sarcoma Cells."
Published in Cancer Weekly, March 30th, 1998
According to the authors' abstract of an article published in Journal of Cellular Biochemistry, "Both clinical and experimental evidence indicates that AIDS-related Kaposi's sarcoma (AIDS-KS) has a multifactorial pathogenesis with factors such as HIV viral load, latent virus induction, and opportunistic infections contributing to disease progression. However, a consistent feature that unites these apparently diverse putative etiologic agents is sustained serum elevations of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha). While virtually every cell responds to TNF-alpha with gene activation, the extent of TNF-alpha-mediated cellular signaling is regulated by a...
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Source: Cancer Weekly (1998-03-30)
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