"Human Melanoma Patients Recognize an HLA-A1-Restricted CTL Epitope From Tyrosinase Containing Two Cysteine Residues: Implications for Tumor Vaccine Development."

According to the authors' abstract of an article published in Journal of Immunology, "To identify shared epitopes for melanoma-reactive CTL restricted by MHC molecules other than HLA-A*0201, six human melanoma patient CTL lines expressing HLA-A1 were screened for reactivity against the melanocyte differentiation proteins Pmel-17/gp100, MART-1/Melan-A, and tyrosinase, expressed via recombinant vaccinia virus vectors. CTL from five of the six patients recognized epitopes from tyrosinase, and recognition of HLA-A1⁺ target cells was strongly correlated with tyrosinase expression. Restriction by HLA-A1 was further demonstrated for two of those tyrosinase-reactive CTL lines. ...

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