Suicide Gene Therapy

HSV-TK/GCV Gene Therapy with a Twist: Nonviral Vector Successful In Vivo

Published in Cancer Weekly, April 27th, 1998

A T7 cancer gene therapy plasmid vector encoding a herpes simplex virus thymidine kinase (HSV-TK) gene (pT7T7/T7TK) was successful, when used in conjunction with subsequent ganciclovir (GCV), in treating established osteosarcoma tumors in a murine model.

In previous research, Xiaozhuo Chen and Yunsheng Li of Progenitor Inc., California, and the Ohio University, described a nonviral cytoplasmic gene therapy vector system based on the T7 autogene concept (Chen et al., Nucleic Acids Res., 1994;322:2114-20). This system showed itself capable of achieving rapid and high levels of gene expression in a variety of animal cells and tissues (Chen et al., Cancer Gene Ther.,...

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Source: Cancer Weekly (1998-04-27)

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