Pathogenesis

Study Finds Drugs That Help Cancer May Block Cure

Published in Cancer Weekly, April 27th, 1998

Some drugs used to fight cancer may actually be blocking their own effects, U.S. researchers said.

The drugs may be too big to get through to the tumors, they said.

Rakesh Jain and colleagues at Harvard Medical School and the Massachusetts General Hospital measured the size of the pores that line the arteries feeding tumors.

As the arteries shrink, so do the pores. They sometimes shrink so much that the drugs can no longer squeeze through, Jain's team reported in the Proceedings of the National Academy of Sciences.

Jain's team grew six different kinds of tumors in specially-bred mice and examined the arteries...

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Source: Cancer Weekly (1998-04-27)

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