Vector Development
Artificial Death Switches Make Vectors Safer
Published in Cancer Weekly, April 27th, 1998
The development of safe vectors for gene therapy is an ever expanding field. An important area of vector design revolves around the development of a fail-safe mechanism that would allow clinicians to terminate therapy or remove the genetically altered cells at the end of treatment or in the case of deleterious effects.
Rebecca A. MacCorkle and colleagues from Baylor College of Medicine, Texas, used chemically induced dimerization to develop powerful death switches based on the cysteine proteases, caspase-1 ICE (interleukn-1(beta) converting enzyme) and...
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Source: Cancer Weekly (1998-04-27)
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