"Mechanisms for Ganciclovir Resistance in Gastrointestinal Tumor Cells Transduced With a Retroviral Vector Containing the Herpes Simplex Virus Thymidine Kinase Gene."

According to the authors' abstract of an article published in Clinical Cancer Research, "Transfer of the herpes simplex thymidine kinase (HSV-TK) gene into tumor cells confers sensitivity to the cells to the viral drug ganciclovir (GCV). Although the efficacy of the HSV-TK/GCV approach is well studied, the mechanisms for the resistance of HSV-TK-transduced tumor cells to GCV are poorly understood. Here, we examined the mechanisms for GCV resistance in HSV-TK-transduced gastrointestinal (GI) cell lines. Our results show that GCV sensitivities vary in vitro and in vivo among the different HSV-TK-transduced GI tumor cell lines. GCV-resistant colonies were isolated from several different...

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