Genetics

In Vivo Data Demonstrate Critical Role for Telomeres

Published in Cancer Weekly, May 4th, 1998

Geron Corp., Menlo Park, California, announced that research which it has funded has provided in vivo proof that telomere loss in the absence of telomerase leads to tissue and organ dysfunction.

In a paper published in the April 9, 1998, issue of Nature, research by Dr. Ron DePinho, Albert Einstein College of Medicine, and Dr. Carole Greider, Johns Hopkins School of Medicine, Baltimore, Maryland, and colleagues showed that telomerase deficient mice suffer a decline in tissue and organ function when, after a certain number of cell divisions, telomeres become critically short. The result points to the telomere as a central mechanism in cell aging.

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Source: Cancer Weekly (1998-05-04)

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