"Inhibition of Growth of Malignant Rat Prostate Tumor Cells by Restoration of Fibroblast Growth Factor Receptor 2."

According to the authors' abstract of an article published in Cancer Research, "A loss of expression of fibroblast growth factor (FGF) receptor 2 IIIb (FGFR2IIIb), which responds to stroma-derived FGF, accompanies progression of premalignant androgen-responsive rat prostate tumor epithelial cells to the malignant phenotype. Concurrently, the level of FGFR2 gene expression is reduced and lost altogether in over 30% of cells, whereas all malignant cells abnormally express FGFR1, which is normally confined to stromal cells (S. Feng et al., Cancer Res., 1997;57:5369-5378). To determine the relative roles of the FGFR2 and FGFR1 kinases in growth of malignant cells, we transfected malignant...

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