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Melanoma

"Is the Survival of Melanoma Patients Receiving Polyvalent Melanoma Cell Vaccine Linked to the Human Leukocyte Antigen Phenotype of Patients?."

Published in Cancer Weekly, May 18th, 1998

According to the authors' abstract of an article published in Journal of Clinical Oncology, "Purpose: An allogeneic polyvalent melanoma cell vaccine (PMCV) has been shown to be efficacious in improving overall survival of patients with malignant melanoma in a Phase II clinical setting. The PMCV consists of three allogeneic melanoma cell lines. The objectives of the study were to determine (1) whether the survival of melanoma patients who received PMCV was related to the patient's human leukocyte antigen (HLA) class I phenotype matching the HLA class I phenotype of the PMCV, and (2) whether PMCV clinical efficacy was correlated to melanoma patients with a particular HLA...

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