Lymphocytic Leukemia
Adhesion of B-CLL Cells to Stromal Cells Prevents Apoptosis
Published in Cancer Weekly, May 25th, 1998
B-chronic lymphocytic leukemia (B-CLL) is a malignant disease that is characterized by the accumulation of mature monoclonal CD5+ B cells. Leukemic B lymphocytes from chronic lymphocytic leukemic patients have a long survival time in vivo, however, ex vivo they die rapidly due to apoptosis.
L. Lagneaux and colleagues, Institut J. Bordet, Brussels, Belgium, investigated the influence of bone marrow (BM) stromal cells from normal individuals on apoptosis of B-CLL cells and normal umbilical cord blood (UCB) B lymphocytes ("Chronic...
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Source: Cancer Weekly (1998-05-25)
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