Cancer Gene Therapy
"Wt-p53 Action in Human Leukaemia Cell Lines Corresponding to Different Stages of Differentiation."
Published in Cancer Weekly, June 22nd, 1998
According to the authors' abstract of an article published in British Journal of Cancer, "Recent studies support the potential application of the wt-p53 gene in cancer therapy. Expression of exogenous wt-p53 suppresses a variety of leukaemia phenotypes by acting on cell survival, proliferation and/or differentiation. As for tumour gene therapy, the final fate of the neoplastic cells is one of the most relevant points. We examined the effects of exogenous wt-p53 gene expression in several leukaemia cell lines to identify p53-responsive leukaemia. The temperature-sensitive p53(Val135) mutant or the human wt-p53 cDNA was transduced in leukaemia...
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Source: Cancer Weekly (1998-06-22)
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