Melanoma
"Ex vivo and in vivo Adenovirus-Mediated Gene Therapy Strategies Induce a Systemic Anti-Tumor Immune Defence in the B16 Melanoma Model."
Published in Cancer Weekly, July 13th, 1998
According to the authors' abstract of an article published in Journal of Investigative Dermatology, "The efficacy of adenovirus-mediated gene therapy for treatment of metastatic B16 melanomas, established in syngeneic C57BL/6 mice, was assessed via an ex vivo cytokine vaccine approach or via an in vivo strategy utilizing combination cytokine/herpes simplex virus-thymidine kinase (HSV-tk) suicide gene delivery and treatment with ganciclovir (GCV). In the ex vivo tumor vaccine approach, B16 melanoma cells, transduced in vitro by adenovirus containing either interleukin (IL)-2, granulocyte-macrophage colony stimulating factor (GM-CSF), or tumor necrosis factor-alpha cytokine genes and gamma...
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Source: Cancer Weekly (1998-07-13)
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