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Genetics (Prostate Cancer)

"A Race Specific Polymorphism in the Human Androgen Receptor - Relationship to Prostate Cancer."

Published in Cancer Weekly, July 13th, 1998

According to an abstract submitted by the authors to the 80th Annual Meeting of The Endocrine Society, held June 24-27, 1998, in New Orleans, Louisiana, "We and others have shown previously that the human androgen receptor contains 2 race specific polymorphisms in the N-terminal transcriptional activation domain. One polymorphism is a triplet repeat encoding polyglutamine that, on average, is shorter in Americans of African descent compared to Americans of Caucasian extraction. The other polymorphism is a triplet repeat encoding polyglycine that is also shorter in African Americans. We now report a third species specific polymorphism in the human Androgen receptor that lies between the...

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