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Multiple Doses of Human Monoclonal Antibody 3622W94 have Acceptable Toxicities

Published in Cancer Weekly, July 13th, 1998

A phase I trial testing multiple doses of the humanized monoclonal antibody (MAb) 3622W94 in cancer patients demonstrated acceptable toxicities.

M.N. Saleh, representing colleagues from the University of Alabama and Glaxo Wellcome, Inc., discussed trial results at the 34th Annual Meeting of the American Society of Clinical Oncology, held May 16-19, 1998, in Los Angeles, California (abstract "Phase I Trial Testing Multiple Doses of Humanized Monoclonal Antibody 3622W94").

"The humanized MAb 3622W94 binds to EPG40 antigen (17-1A antigen), which is prevalent on most adenocarcinomas," stated Saleh et al. "PANOREX, a murine MAb that binds the same...

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