Oncology

NK-208 is Cytotoxic in Leukemia Cell Lines

Published in Cancer Weekly, July 27th, 1998

The sulfated glycoglycerolipid KN-208 was modestly cytotoxic for a human leukemic cell line in a Japanese study.

"Our results suggest that the whole molecular structure of KN-208 is required for inhibition," A. Ogawa and colleagues from Nagoya University wrote ("Sulfated Glycoglycerolipid From Archaebacterium Inhibits Eukaryotic DNA Polymerase Alpha, Beta, and Retroviral Reverse Transcriptase and Affects Methyl Methanesulfonate Cytotoxicity," International Journal of Cancer, May 18, 1998;76(4):512-518).

A sulfated glycoglycerolipid, 1-0-(6'-sulfo-alpha-D-glucopyranosyl)-2,3-di-O-phy tanyl- sn-glycerol (KN-208), a derivative of the polar lipid...

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Source: Cancer Weekly (1998-07-27)

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