Cancer Immunotherapy

Research Provides New Information about IL-12's Role in Angiogenesis

Published in Cancer Weekly, August 10th, 1998

Interleukin-12 (IL-12) is known to engage in potent anti-tumor activities. Until recently, however, the biological events governing its behavior were little understood.

New information about IL-12, unearthed by scientists working in the laboratories of Dr. Giorgio Trinchieri at Wistar, Philadelphia, Pennsylvania, where the cytokine was discovered in the mid-1980s, and Dr. William M.F. Lee at the University of Pennsylvania, in Philadelphia, appeared in the July 24, 1998, issue of Immunity.

IL-12 provokes a series of events that ultimately interfere with angiogenesis, or the formation of blood vessels that nourish and enlarge tumors. Without...

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Source: Cancer Weekly (1998-08-10)

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