Immunotoxins
"Anti-Prostate Immunotoxins: Cytotoxicity of E4 Antibody-Pseudomonas exotoxin Constructs."
Published in Cancer Weekly, September 7th, 1998
According to the authors' abstract of an article published in International Journal of Cancer, "E4 is a monoclonal antibody (MAb) that reacts with a surface antigen present on normal prostate and prostate cancers. Using this antibody, 2 immunotoxins were generated, one being a chemical conjugate with a mutant truncated form of Pseudomonas exotoxin A (PE), E4-PE35KDEL. The other is a recombinant single chain immunotoxin, E4(FV)PE38KDEL. The affinity of the conjugated immunotoxin was similar to the hybridoma-produced MAb E4, revealing that conjugation did not impair the binding ability. The affinity of the recombinant immunotoxin (10 nM) was 10-fold lower than that of the MAb,...
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Source: Cancer Weekly (1998-09-07)
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