Published in Cancer Weekly, September 28th, 1998
The human retinoblastoma gene, RB1, is one of the most well-characterized tumor-suppressor genes. The RB1 gene product, RB protein, causes cell cycle arrest in the G0 /G1 phase by inhibiting transcription factors.
As a prelude to considering RB gene therapy for cancer, G. William Demers and colleagues from Canji, Inc., California, and the Schering-Plough Research Institute, New Jersey, conducted a series of in vitro and in vivo experiments using a recombinant...
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