Published in Cancer Weekly, October 5th, 1998
Several different murine models have demonstrated that the immunogenicity of tumor cells can be increased by transduction with a range of immunostimulatory genes which induce an immune response that causes regression of pre-existing unmodified tumor cells. In order to investigate the relevance of these animal models to clinical situations with pediatric patients, Laura Bowman and colleagues from St. Jude Children's Research Hospital and the Memphis College of Medicine, Tennessee, used autologous unirradiated tumor cells transduced with an adenovirus-IL-2 to immunize...
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