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Patent Awarded for Two-Antibody Cancer Fighting Strategy

Published in Cancer Weekly, November 2nd, 1998

Researchers at the University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, were awarded a U.S. patent for a technology that has shown the potential in laboratory studies to cure breast and other major cancers linked to certain abnormal genes.

The approach targets cancer-causing receptor molecules found on the surface of tumor cells with two different antibodies that bind to the molecules, fatally disabling the receptor's activity and leading to the cancer cell's death.

The specific application of the concept detailed in the patent employs a pair of antibodies against a receptor protein called p185. The p185 protein assembles into a...

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