Pathogenesis (Kaposi's Sarcoma)
"HHV-8, Proliferation, Apoptosis and Ploidy in Epidemic (AKS), Endemic (EKS), and Classical (CKS) Kaposi's Sarcoma LE
Published in Cancer Weekly, November 9th, 1998
According to an abstract submitted by the authors to the 12th World AIDS Conference, held June 28 - July 3, 1998, in Geneva, Switzerland, "Objectives: To study the possible interrelationship of HHV8 infection, cell proliferation, apoptosis and ploidy in AIDS associated (AKS), endemic Kaposi's sarcoma (EKS) and classical Kaposi's sarcoma (CKS). Design: Prospective, controlled study. Methods: Formalin fixed and frozen biopsies of KS were studied by PCR and in situ hybridization (ISH) for HHV8-DNA and sequencing of the KS330 Bam fragment. Ploidy was done by flow cytometry of cell nuclei from KS spindle cells (SC). Immunohistochemistry was done for Ki67, bcl-2,...
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Source: Cancer Weekly (1998-11-09)
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