Colon Cancer (Etiology)

Researchers Find Genetic Cancer Change in Healthy Cells

Published in Cancer Weekly, November 9th, 1998

Scientists from Johns Hopkins Medical Institutes, Baltimore, Maryland, have found a genetic alteration associated with common forms of colon cancer in patients' normal cells.

The same abnormality, called loss of imprinting (LOI), also appears, the researchers said, in a significant number of healthy people, offering a possibility of predicting as many as 40 percent of new colon cancer cases before they start.

"It's the first cancer-related genetic alteration found at high frequency in healthy people," said Andrew P. Feinberg, MD, who, with Hengmi Cui, PhD, led the study which appeared in the October 1998 issue of Nature Medicine. By contrast, APC...

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Source: Cancer Weekly (1998-11-09)

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