Published in Cancer Weekly, November 9th, 1998
Suicide gene therapy has undergone intense scrutiny as a potential anticancer therapeutic. The HSVtk/GCV system has received the most study because the efficacy of this approach is enhanced by the bystander effect. However, the treatment of malignancies with an adenovirus (Ad) vector can lead to the transduction of cells that are not cancerous. Ad vectors ofttimes preferentially collect in the liver, leading to the potential transduction of normal cells. The...
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