Cancer Vaccines

Potent Antitumor Effect Seen In Late-Stage Patients

Published in Cancer Weekly, November 23rd, 1998

Eleven of 16 patients who received a vaccine based on their own metastatic melanoma cells had a powerful antitumor response.

The vaccine consisted of autologous melanoma cells transfected with human granulocyte-macrophage colony-stimulating factor (GM-CSF) and then lethally irradiated.

"Metastatic lesions resected after vaccination were densely infiltrated with T lymphocytes and plasma cells and showed extensive tumor destruction (at least 80 percent), fibrosis, and edema," wrote Robert Soiffer and Glenn Dranoff of Harvard Medical School, Boston, Massachusetts, and colleagues.

Soiffer et al. reported their findings in the journal...

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Source: Cancer Weekly (1998-11-23)

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