Cancer Immunotherapy

Chromosomal Aberrations Responsible for Failed Therapy

Published in Cancer Weekly, November 23rd, 1998

Genetic analysis explains the pathogenesis of failed cancer immunotherapy.

Research based on conventional cytogenetic studies of tumor cells from patients with breast or ovarian cancer have shown multiple chromosomal abnormalities including chromosomes 7, 12, and 17. H. Engel and colleagues from the University of Cologne, Germany, examined these abnormalities to better understand prognostic factors associated with gynecological cancers ("Detection of Chromosomal Aberrations in Tumor Cells and Tumor Infiltrating Lymphocytes by Molecular Cytogenetics in Patients with Gynecological Cancer," Cancer Genetics and Cytogenetics, October 15, 1998;106(2):159-165).

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Source: Cancer Weekly (1998-11-23)

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