Leukemia (Therapy)

Targeting PML/RAR Alpha has Therapeutic Potential

Published in Cancer Weekly, November 23rd, 1998

Targeting PML/RAR alpha expression may have therapeutic potential in acute promyelocytic leukemia (APL).

Studies have determined that the t(15;17) rearrangement found in acute promyelocytic leukemia yields a fusion transcript called PML/RAR alpha. It has been shown that PML/RAR alpha expression is linked to leukemogenesis and to clinical sensitivity to all-trans retinoic acid (RA). Although, in a weird paradox, RA treatment causes transient complete remissions in most t(15;17) APL cases.

However, K. Nasonburchenal and colleagues from the Memorial Hospital, New York, New York noted that the precise roles of PML/RAR alpha in triggering leukemia or in...

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Source: Cancer Weekly (1998-11-23)

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