Cancer Immunotherapy

New Melanoma Antigen Discovered

Published in Cancer Weekly, November 30th, 1998

A new shared human melanoma antigen has been identified.

R. Lupetti and colleagues from the National Cancer Institute, Italy, reported the identification of a new shared human melanoma antigen that is recognized by a human leukocyte antigen (HLA)-A*68011-restricted cytotoxic T lymphocyte clone (CTL 128) ("Translation of a Retained Intron in Tyrosinase-Related Protein (TRP) 2 mRNA Generates a New Cytotoxic T Lymphocyte (CTL)-Defined and Shared Human Melanoma Antigen Not Expressed in Normal Cells of the Melanocytic Lineage," Journal of Experimental Medicine, September 21, 1998;188(6):1005-1016).

"The cDNA encoding this antigen is composed of a...

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Source: Cancer Weekly (1998-11-30)

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