"Antibodies to PECAM-1 Inhibit the Growth of Human Non-Small Cell Lung Cancer in SCID Mice."

According to an abstract submitted by the authors to the American Thoracic Society, 1998 International Conference, held April 25-29, 1998, in Chicago, Illinois, "It has been recently shown that antibodies against the endothelial cell-cell adhesion molecule, PECAM-1, inhibited tube formation by rat capillary endothelial cells and cytokine-induced rat corneal neovascularization and in mice prevented vessel growth into subcutaneously implanted gels supplemented with bFGF (Am J Path 1997, 151:671-677). However its potential role in tumor angiogenesis is not known. We therefore looked at the effect of anti-murine PECAM-1 antibody on the growth of A549 human lung cancer cells injected...

Want to see the full article?

• Purchase this article for only $3.00