Immunology

Immune System Master Switch Cuts Off Tumors

Published in Cancer Weekly, December 7th, 1998

Scientists believe they have found a "master switch" that allows tumors to use various tricks to evade the body's immune system.

It's a protein called PML. If it works, killer T cells in the body's immune system go into battle against cancerous cells. If it doesn't, the tumor takes over with devastating consequences.

"The master switch controls whether killer cells can recognize the tumor," Dr. Yang Liu, Ohio State University Medical Center in Columbus, Ohio, said in a telephone interview.

PML works by controlling several genes that produce and transport a major histocompatibility complex (MHC) - comprising a peptide and...

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Source: Cancer Weekly (1998-12-07)

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