Suicide Gene Therapy

Tissue-Specific Promoter Targets Cervical Cancer

Published in Cancer Weekly, December 7th, 1998

Use of a tissue-specific promoter (TSP) helps researchers target suicide gene therapy to cervical carcinoma cells.

Although several targeted gene therapy strategies have been developed for a number of epithelial malignancies (S.A. Rosenberg et al., Hum Gene Ther., 1996;7:2287-313), these strategies have not been explored in the context of carcinoma of the cervix. Several factors, however, suggest that cervical cancer may be a good candidate for a suicide gene therapy approach.

Matthew W. Robertson III and colleagues from the University of Alabama suggested that the limitations for applying molecular chemotherapy strategies to cervical carcinoma have...

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Source: Cancer Weekly (1998-12-07)

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