"Augmentation of Therapeutic Antitumor Immunity by B16F10 Melanoma Cells Transfected with Interferon-gamma and Allogeneic MHC Class I cDNAs."

According to the authors' abstract of an article published in Molecules and Cells, "The cDNAs for interferon-gamma (IFN-gamma) and allogeneic H-2K(d) molecules were transfected into highly metastatic B16F10 melanoma cells (H-2(b)), and the synergistic effects of the antitumor immune responses by the doubly transfected cells (B16/K-d/IFN-gamma cells) were investigated in C57BL/6 mice (H-2(b)). The singly transfected B16F10 cells with either IFN-gamma or H-2K(d) cDNA (B16/IFN-gamma or B16/K-d cells) were used as controls. The B16/K-d/IFN-gamma cells secreted biologically active IFN-gamma, and strongly expressed both syngeneic and allogeneic MHC class I antigens (H-2K(b) and H-2K(d)) on the...

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