"Vascular Integrin alpha(v)beta(3): A New Prognostic Indicator in Breast Cancer."

According to the authors' abstract of an article published in Clinical Cancer Research, "Blood vessel density is a prognostic indicator of multiple tumor types. Recently, it has been established that tumor-associated blood vessels express elevated levels of integrin alpha(v)beta(3). In fact, there is evidence that integrin alpha(v)beta(3) identifies the most proliferative endothelial cells within human breast carcinomas. Therefore, we evaluated breast cancer tissue in terms of both blood vessel density and alpha(v)beta(3) expression. We found that the antibody LM609 to integrin alpha(v)beta(3) preferentially stains the blood vessels of small caliber. Furthermore, comparative studies...

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