Kaposi's Sarcoma

Angiogenesis Inhibition Demonstrated in HIV Associated KS Model

Published in Cancer Weekly, December 21st, 1998

ImClone Systems, Inc., presented preclinical data demonstrating that monoclonal antibodies which are highly specific inhibitors of human vascular endothelial cell growth factor VEGF receptor-2 (VEGFR-2) can prevent the growth of blood vessels in an in vitro model of AIDS associated Kaposi's sarcoma (KS).

The data were presented by Shahin Rafii, MD, of Cornell University Medical College, at the 40th Annual American Society of Hematology Meeting, held in Miami, Florida, during December 1998. KS is caused by the malignant proliferation of blood vessel (endothelial) cells in HIV infected patients. Previous studies have found that co-infection with human herpesvirus 8...

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Source: Cancer Weekly (1998-12-21)

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